Cochrane Corner: Antihypertensive efficacy of beta-1 selective beta blockers for primary hypertension
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منابع مشابه
Cochrane corner: beta-blockers for hypertension
BaCkground Beta-blockers refer to an assorted group of medications that block the action of endogenous catecholamines on beta-adrenergic receptors. The β1 and β2 receptors are the primary beta-adrenergic receptors in the human cardiovascular system. Betablockers differ in their β1/β2-receptor selectivity and vasodilatory properties. Based on this diversity, beta-blockers have been categorised i...
متن کاملBeta-blockers for hypertension
BACKGROUND Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension. Howev...
متن کاملReview: Beta blockers are less effective than other antihypertensive drugs for reducing risk of stroke in primary hypertension.
M e t h o d s Data sources: PubMed and the Cochrane Library. Study selection and assessment: Randomized controlled trials (RCTs) that compared β-blockers as first-line treatment with placebo, no treatment, or other antihypertensive drugs in patients with primary hypertension, and evaluated all-cause mortality, cardiovascular morbidity, or both. Subgroup analyses were conducted for nonatenolol β...
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Hypertension is a common condition in developed and developing nations, associated with cardiovascular complications and end organ damage, and yet its etiology remains largely elusive. It has long been recognized that satisfactory control of blood pressure reduces cardiovascular complications. Early trials, before the advent of drugs acting on the renin-aldosterone system, (RAS) revealed the th...
متن کاملMeta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol).
Because carvedilol is a unique vasodilating β blocker (BB) exerting antioxidant activity and pleiotropic effects, it was theorized that it may confer more potent beneficial effects on cardiovascular mortality and morbidity in acute myocardial infarction (AMI) and heart failure (HF) settings. A systematic review and meta-analysis was performed of randomized, controlled, direct-comparison trials ...
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ژورنال
عنوان ژورنال: Revista Portuguesa de Cardiologia (English Edition)
سال: 2017
ISSN: 2174-2049
DOI: 10.1016/j.repce.2016.09.012